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Methadone is a long-acting opioid medication used both for severe chronic pain and for maintenance or detoxification therapy in opioid use disorder (OUD). Its mechanism involves full agonism at the μ-opioid receptor (and NMDA antagonism), which helps relieve withdrawal symptoms and cravings more safely over time.

However, in many jurisdictions methadone is tightly regulated: in the U.S., methadone for OUD must be dispensed via certified opioid treatment programs (OTPs), not conventional pharmacies. It carries risks of respiratory depression.